4.6 Article

A deep look into radiomics

Journal

RADIOLOGIA MEDICA
Volume 126, Issue 10, Pages 1296-1311

Publisher

SPRINGER-VERLAG ITALIA SRL
DOI: 10.1007/s11547-021-01389-x

Keywords

Radiomics; Medical imaging; Features; Imaging biomarkers; Personalized medicine

Funding

  1. Universita di Pisa within the CRUI-CARE Agreement
  2. HORIZON 2020 project CHAIMELEON [952172]
  3. HORIZON 2020 project PRIMAGE [826494]
  4. HORIZON 2020 project EuCanImage [952103]
  5. HORIZON 2020 project Procancer-I [952159]

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This review provides a detailed look into radiomics, covering its basis, technical applications, challenges, and potential in precision medicine. It discusses techniques used in the radiomics workflow and highlights promising results achieved in various applications, with a focus on limitations and possible solutions for clinical implementation. An in-depth and comprehensive understanding of current methods and applications is crucial in realizing the potential power of radiomics in improving patient care, especially in cancer detection, diagnosis, prognosis, and treatment evaluation.
Radiomics is a process that allows the extraction and analysis of quantitative data from medical images. It is an evolving field of research with many potential applications in medical imaging. The purpose of this review is to offer a deep look into radiomics, from the basis, deeply discussed from a technical point of view, through the main applications, to the challenges that have to be addressed to translate this process in clinical practice. A detailed description of the main techniques used in the various steps of radiomics workflow, which includes image acquisition, reconstruction, pre-processing, segmentation, features extraction and analysis, is here proposed, as well as an overview of the main promising results achieved in various applications, focusing on the limitations and possible solutions for clinical implementation. Only an in-depth and comprehensive description of current methods and applications can suggest the potential power of radiomics in fostering precision medicine and thus the care of patients, especially in cancer detection, diagnosis, prognosis and treatment evaluation.

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