4.5 Article

Lack of association between severity of ADHD symptoms and salivary oxytocin levels

Journal

PSYCHONEUROENDOCRINOLOGY
Volume 131, Issue -, Pages -

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.psyneuen.2021.105293

Keywords

Oxytocin; Social cognition; Attention deficit hyperactivity disorder (ADHD)

Funding

  1. Brain and Behavior Research Foundation [21165]

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This study did not find a statistical correlation between the severity of ADHD symptoms and salivary OT levels in children. It suggests that impairments in the reactivity of the OT system, associated with interpersonal difficulties, may be a distinct aspect of the clinical presentation of ADHD, different from other symptoms.
Impairments in the reactivity of Oxytocin (OT) system were associated with interpersonal difficulties in children with ADHD. The current study aimed to explore the correlation between symptoms severity and salivary OT levels at different time-points in children with ADHD. Symptoms severity was assessed in 50 children with ADHD (28 males, mean age 9.42 +/- 1.65) using the Swanson, Nolan and Pelham Questionnaire-IV (SNAP-IV) and the Strengths and Difficulties Questionnaire (SDQ). Salivary OT levels were measured at baseline, as well as 15 min after positive social interaction. There was no statistical correlation between severity of ADHD and salivary OT levels in each of the time points. We conclude that impairments in the reactivity of the OT system in children with ADHD, associated with interpersonal impairments, might be a distinct aspect of the clinical picture, differentiated from the levels of inattentive, hyperactive/impulsive or behavioral symptoms.

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