Journal
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS
Volume 89, Issue 12, Pages 1977-1986Publisher
WILEY
DOI: 10.1002/prot.26213
Keywords
benchmarking; blind assessment; continuous evaluation; macromolecular complexes; non-canonical residues; molecular structure prediction; ligands
Categories
Funding
- National Institute of General Medical Sciences [U01 GM093324-01]
- Swiss Institute of Bioinformatics
- ELIXIR EXCELERATE
Ask authors/readers for more resources
CAMEO platform complements the biennial CASP experiment by conducting fully automated blind evaluations of protein structure predictions, focusing on challenging areas such as protein complexes. This will assist in new developments in these research areas.
The Continuous Automated Model EvaluatiOn (CAMEO) platform complements the biennial CASP experiment by conducting fully automated blind evaluations of three-dimensional protein prediction servers based on the weekly prerelease of sequences of those structures, which are going to be published in the upcoming release of the Protein Data Bank. While in CASP14, significant success was observed in predicting the structures of individual protein chains with high accuracy, significant challenges remain in correctly predicting the structures of complexes. By implementing fully automated evaluation of predictions for protein-protein complexes, as well as for proteins in complex with ligands, peptides, nucleic acids, or proteins containing noncanonical amino acid residues, CAMEO will assist new developments in those challenging areas of active research.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available