4.3 Review

Cellular evolution as the flow of energy

Journal

PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY
Volume 167, Issue -, Pages 147-151

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pbiomolbio.2021.06.011

Keywords

Darwinian evolution; Epigenetic evolution; Ontogeny; Phylogeny; Energy flow; First principles of physiology

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Cellular epigenetic evolution emphasizes cell-cell communication and injury-repair, merging ontogeny and phylogeny through communication to form a unified evolutionary process. The goal of evolution is energy flow, with only the flow of energy remaining once the superficial material aspects of lifeforms are eliminated.
In contrast to Darwinian evolution, which is founded on the material competition between organisms, cellular epigenetic evolution focuses on cell-cell communication of data from one stage of life to another developmentally, phylogenetically, as injury-repair ultimately governed by the First Principles of Physiology. By merging ontogeny and phylogeny, since both are based on cell-cell communication mediated by soluble growth factors and their receptors, evolution complies as one holistic, unified process. As such, the material aspects of the organism can be seen as 'means' instead of 'ends', begging the question as to just what the 'ends' of evolution are ? Once the superficial material aspect of lifeforms is eliminated, only the flow of energy is left, within and between generations. Contemporary biology and physics are at a critical phase, unable to reduce their problems to practice. A paradigm shift to evolution as energy flow is proposed as the solution. (c) 2021 Elsevier Ltd. All rights reserved.

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