4.8 Article

Siglecs-7/9 function as inhibitory immune checkpoints in vivo and can be targeted to enhance therapeutic antitumor immunity

Related references

Note: Only part of the references are listed.
Article Multidisciplinary Sciences

Modulation of immune cell reactivity with cis-binding Siglec agonists

Corleone S. Delaveris et al.

Summary: The synthetic lipid-conjugated glycopolypeptides can insert into cell membranes and engage Siglec receptors in cis, leading to inhibitory signaling. These cis-binding agonists of Siglecs provide a method for therapeutic suppression of immune cell reactivity, modulating signaling pathways in various cell types.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

Article Medicine, General & Internal

Anti-Siglec-8 Antibody for Eosinophilic Gastritis and Duodenitis

Evan S. Dellon et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Article Multidisciplinary Sciences

Targeting a scavenger receptor on tumor-associated macrophages activates tumor cell killing by natural killer cells

Silke Eisinger et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Review Cell Biology

Current Status on Therapeutic Molecules Targeting Siglec Receptors

Maria Pia Lenza et al.

CELLS (2020)

Article Biochemistry & Molecular Biology

Siglec-15 as an immune suppressor and potential target for normalization cancer immunotherapy

Jun Wang et al.

NATURE MEDICINE (2019)

Article Multidisciplinary Sciences

CD24 signalling through macrophage Siglec-10 is a target for cancer immunotherapy

Amira A. Barkal et al.

NATURE (2019)

Article Multidisciplinary Sciences

The glycan CA19-9 promotes pancreatitis and pancreatic cancer in mice

Dannielle D. Engle et al.

SCIENCE (2019)

Article Medicine, Research & Experimental

Antibodies targeting sialyl Lewis A mediate tumor clearance through distinct effector pathways

Polina Weitzenfeld et al.

JOURNAL OF CLINICAL INVESTIGATION (2019)

Article Medicine, Research & Experimental

Self-associated molecular patterns mediate cancer immune evasion by engaging Siglecs on T cells

Michal A. Stanczak et al.

JOURNAL OF CLINICAL INVESTIGATION (2018)

Review Oncology

Resistance to PD1/PDL1 checkpoint inhibition

Jake S. O'Donnell et al.

CANCER TREATMENT REVIEWS (2017)

Review Biochemistry & Molecular Biology

Primary, Adaptive, and Acquired Resistance to Cancer Immunotherapy

Padmanee Sharma et al.

Review Biochemistry & Molecular Biology

Sialic acids in cancer biology and immunity

Oliver M. T. Pearce et al.

GLYCOBIOLOGY (2016)

Article Biochemistry & Molecular Biology

Melanoma Cell-Intrinsic PD-1 Receptor Functions Promote Tumor Growth

Sonja Kleffel et al.

Article Multidisciplinary Sciences

IL-17-producing γδ T cells and neutrophils conspire to promote breast cancer metastasis

Seth B. Coffelt et al.

NATURE (2015)

Article Biochemistry & Molecular Biology

Lectin Galactoside-binding Soluble 3 Binding Protein (LGALS3BP) Is a Tumor-associated Immunomodulatory Ligand for CD33-related Siglecs

Heinz Laeubli et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2014)

Article Medicine, Research & Experimental

Interactions between Siglec-7/9 receptors and ligands influence NK cell-dependent tumor immunosurveillance

Camilla Jandus et al.

JOURNAL OF CLINICAL INVESTIGATION (2014)

Article Biochemistry & Molecular Biology

Glycocalyx engineering reveals a Siglec-based mechanism for NK cell immunoevasion

Jason E. Hudak et al.

NATURE CHEMICAL BIOLOGY (2014)

Article Multidisciplinary Sciences

Engagement of myelomonocytic Siglecs by tumor-associated ligands modulates the innate immune response to cancer

Heinz Laubli et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Review Immunology

Siglec-mediated regulation of immune cell function in disease

Matthew S. Macauley et al.

NATURE REVIEWS IMMUNOLOGY (2014)

Article Biochemistry & Molecular Biology

Siglecs as sensors of self in innate and adaptive immune responses

James C. Paulson et al.

GLYCOBIOLOGY OF THE IMMUNE RESPONSE (2012)

Article Multidisciplinary Sciences

Myeloid Suppressor Cell Depletion Augments Antitumor Activity in Lung Cancer

Minu K. Srivastava et al.

PLOS ONE (2012)

Article Biochemistry & Molecular Biology

Immunomodulation of monocyte-derived dendrite cells through ligation of tumor-produced mucins to Siglec-9

Mariko Ohta et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2010)

Review Immunology

Siglecs and their roles in the immune system

Paul R. Crocker et al.

NATURE REVIEWS IMMUNOLOGY (2007)

Article Multidisciplinary Sciences

Divergent immunoglobulin G subclass activity through selective Fc receptor binding

F Nimmerjahn et al.

SCIENCE (2005)

Article Immunology

FcγRIV:: A novel FcR with distinct IgG subclass specificity

F Nimmerjahn et al.

IMMUNITY (2005)