A reusable and heterogeneous Ti(IV) anchored MCM-41 catalyzed hydroacylation and hydroamination reactions

An efficient, mild and reusable catalytic hydroacylation and hydroamination reactions have been developed by using heterogeneous Ti(IV) anchored MCM-41 catalyst from various aryl, heteroaryl, aliphatic aldehydes as well as aryl and aliphatic amines with dialkyl azodicarboxylate. The catalyst gives excellent yields of desired products, a wide range of substrate scope in hydroacylation and hydroamination and para-selectivity is observed with unprotected amines. The catalyst (Ti-MCM-41) was prepared by a modified strategy and reused more than five catalytic cycles without any significant yield loss in these reactions.

Automated summary

An efficient, mild, and reusable catalytic hydroacylation and hydroamination reactions were developed using heterogeneous Ti(IV) anchored MCM-41 catalyst from various aryl, heteroaryl, aliphatic aldehydes as well as aryl and aliphatic amines with dialkyl azodicarboxylate. The catalyst showed excellent yields, a wide substrate scope, and para-selectivity with unprotected amines.