Journal
PLOS ONE
Volume 16, Issue 9, Pages -Publisher
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pone.0256621
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Funding
- RSF [19-15-00132]
- RFBR [19-3290087]
- Russian Science Foundation [19-15-00132] Funding Source: Russian Science Foundation
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This study provides a detailed analysis of spectral and time-resolved photoprocesses in human platelets and their complexes with platinum nanoparticles, revealing the possibility of energy transfer between Pt NPs and the platelet membrane. The potential application of Pt NPs in quenching-based sensing for pathology diagnosis based on platelet conformations related to cardiovascular diseases is demonstrated.
This paper describes a detailed study of spectral and time-resolved photoprocesses in human platelets and their complexes with platinum (Pt) nanoparticles (NPs). Fluorescence, quantum yield, and platelet amino acid lifetime changes in the presence and without femtosecond ablated platinum NPs have been studied. Fluorescence spectroscopy analysis of main fluorescent amino acids and their residues (tyrosine (Tyr), tryptophan (Trp), and phenylalanine (Phe)) belonging to the platelet membrane have been performed. The possibility of energy transfer between Pt NPs and the platelet membrane has been revealed. Forster Resonance Energy Transfer (FRET) model was used to perform the quantitative evaluation of energy transfer parameters. The prospects of Pt NPs usage deals with quenching-based sensing for pathology's based on platelet conformations as cardiovascular diseases have been demonstrated.
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