Journal
PLOS ONE
Volume 16, Issue 7, Pages -Publisher
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pone.0255377
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Funding
- Feuer International Scholarship in Artificial Intelligence
- Research England's Expanding Excellence in England (E3) fund
- Alan Turing Institute (EPSRC) [EP/N510129]
- University of Warwick IAA funding
- NIHR Exeter Clinical Research Facility
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This study found a significant increase in mortality for COVID-19 patients admitted to ICU during periods of serious operational problems, indicating the need for further research to determine if this association could serve as a valid prognostic marker for deteriorating quality of care.
Objectives To describe the relationship between reported serious operational problems (SOPs), and mortality for patients with COVID-19 admitted to intensive care units (ICUs). Design English national retrospective cohort study. Setting 89 English hospital trusts (i.e. small groups of hospitals functioning as single operational units). Patients All adults with COVID-19 admitted to ICU between 2nd April and 1st December, 2020 (n = 6,737). Interventions N/A Main outcomes and measures Hospital trusts routinely submit declarations of whether they have experienced 'serious operational problems' in the last 24 hours (e.g. due to staffing issues, adverse weather conditions, etc.). Bayesian hierarchical models were used to estimate the association between in-hospital mortality (binary outcome) and: 1) an indicator for whether a SOP occurred on the date of a patient's admission, and; 2) the proportion of the days in a patient's stay that had a SOP occur within their trust. These models were adjusted for individual demographic characteristics (age, sex, ethnicity), and recorded comorbidities. Results Serious operational problems (SOPs) were common; reported in 47 trusts (52.8%) and were present for 2,701 (of 21,716; 12.4%) trust days. Overall mortality was 37.7% (2,539 deaths). Admission during a period of SOPs was associated with a substantially increased mortality; adjusted odds ratio (OR) 1.34 (95% posterior credible interval (PCI): 1.07 to 1.68). Mortality was also associated with the proportion of a patient's admission duration that had concurrent SOPs; OR 1.47 (95% PCI: 1.10 to 1.96) for mortality where SOPs were present for 100% compared to 0% of the stay. Conclusion and relevance Serious operational problems at the trust-level are associated with a significant increase in mortality in patients with COVID-19 admitted to critical care. The link isn't necessarily causal, but this observation justifies further research to determine if a binary indicator might be a valid prognostic marker for deteriorating quality of care.
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