Journal
PLASMA PROCESSES AND POLYMERS
Volume 18, Issue 10, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ppap.202100070
Keywords
cold atmospheric plasma; hyperthermia; intravesical perfusion; plasma-treated medium; reactive oxygen species
Funding
- National Natural Science Foundation of China [51677147, 51837008, 51907158]
- China Postdoctoral Science Foundation [2019M663714]
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The combination of plasma-treated medium and hyperthermia shows better antitumor effects on bladder tumors, promoting the penetration of reactive oxygen species into cancer cells. This novel strategy may serve as a valuable therapeutic option for bladder cancer.
As a form of cold atmospheric plasma application, plasma-treated solutions have shown promise in tumor therapy. Especially for the treatment of intracavitary tumors, plasma-treated solutions combined with traditional perfusion therapy have strong application potential. Here, we assessed the antitumor effects of the plasma-treated medium combined with hyperthermia on three-dimensional bladder tumor spheroids in vitro. We found that the combined treatment of plasma-treated medium and hyperthermia (43 degrees C) presented better antitumor effects than a single treatment. Further research showed that synchronous hyperthermia can promote the penetration of plasma-generated reactive oxygen species from the plasma-treated medium into cancer cells. Our results suggest that hyperthermic perfusion therapy using plasma-treated solutions may serve as a novel and valuable therapeutic strategy for bladder cancer.
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