Journal
PHYTOTHERAPY RESEARCH
Volume 35, Issue 11, Pages 6335-6342Publisher
WILEY
DOI: 10.1002/ptr.7282
Keywords
garlic; PCOS; polycystic ovary syndrome; serum lipids
Categories
Funding
- GolDaroo company
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The study showed that garlic supplementation has a positive impact on lipid parameters in PCOS patients, reducing total cholesterol and LDL-C levels, and possibly lowering triglyceride levels and systolic blood pressure. Further research is needed to confirm these findings.
Polycystic ovary syndrome (PCOS) is the most prevalent female endocrine-related disorder in reproductive ages. The aim of the study was to investigate the effect of garlic on the lipid parameters and blood pressure levels in women with PCOS. The present study was a randomized, double-blinded control trial, conducted on 80 PCOS patients. Participants were taught to intake either a total 800 mg/day garlic supplement or an identical placebo (starch) after lunch for 8 weeks. Physical activity, diet intake, anthropometric measures, and blood pressure were evaluated at baseline and end of the study. The blood sample was also taken to assess the change in outcomes of interest at the pre- and post-intervention. Garlic supplementation significantly reduced serum total cholesterol (change mean difference: -8.05, 95% CI: -15.47, -0.62) and LDL-C (change mean difference: -7.67, 95%CI: -14.64, -0.70) levels in comparison to the control group. In addition, a trend to a significant decrease was found in serum triglyceride levels and Systolic blood pressure; however, no significant difference was observed between two groups in HDL-C and diastolic blood pressure levels. The present study suggested that garlic supplementation might be effective on lipid markers improvement. Further studies are needed to confirm our findings.
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