Journal
PHYTOCHEMISTRY LETTERS
Volume 43, Issue -, Pages 45-52Publisher
ELSEVIER
DOI: 10.1016/j.phytol.2021.02.010
Keywords
Scorzonera aucheriana; Dihydroisocoumarins; Isolation; Antimicrobial activity
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Funding
- Karadeniz Technical University [KTU-BAP 8133]
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Three new dihydroisocoumarin glycosides and five known compounds were isolated from Scorzonera aucheriana in Turkey, with iso-scorzopygmaecoside, scorzoaucherioside I, and 3,4-dihydroxyphenyl caffeate showing notable antimicrobial activity. Iso-scorzopygmaecoside and scorzoaucherioside II exhibited strong activity against Mycobacterium smegmatis.
Three new dihydroisocoumarin glycosides (iso-scorzopygmaecoside, scorzoaucherioside I, and scorzoaucherioside II) together with five known compounds (scorzopygmaecoside, scorzocreticoside II, 3,5-O-dicaffeoyl-epiquinic acid, 3,5-O-dicaffeoylquinic acid, and 3,4-dihydroxyphenyl caffeate) were isolated from the aerial parts of the Scorzonera aucheriana collected from Sivas province in Turkey. The isolated compounds' structures were elucidated based on NMR (1H, 13C/APT, COSY, HMBC, HSQC, and TOCSY), UV, FT-IR, and LC-QTOF-MS data. These compounds have been isolated for the first time from S. aucheriana. An antimicrobial assay against ten microorganisms was applied to all isolated compounds. Iso-scorzopygmaecoside, scorzoaucherioside I, and 3,4dihydroxyphenyl caffeate showed notable anti-pseudomonal activity. Iso-scorzopygmaecoside and scorzoaucherioside II exhibited strong activity against Mycobacterium smegmatis with MIC values of 25.6 mu g/mL and 21.2 mu g/mL, respectively.
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