Journal
PHYTOCHEMISTRY LETTERS
Volume 43, Issue -, Pages 173-178Publisher
ELSEVIER
DOI: 10.1016/j.phytol.2021.03.011
Keywords
Sesquiterpene lactones; Argyoxynolides; Artemisia argyi; Nitric oxide
Categories
Funding
- Program for Changjiang Scholars and Innovative Research Team in University [IRT_15R63]
- 111 Project from the Ministry of Education of China
- State Administration of Foreign Export Affairs of China [B18056]
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Four new highly oxidized sesquiterpene lactones, Argyoxynolides A-D, were isolated from Artemisia argyi H.Le ' v. & Vaniot, along with two known analogs. One of the compounds showed inhibitory activity against LPS-induced nitric oxide production, with an IC50 value of 37.95 +/- 4.39 μM. The structures of these compounds were characterized using extensive spectroscopic methods.
Four new highly oxidized sesquiterpene lactones, Argyoxynolides A-D, along with two known analogs were isolated from the leaves of Artemisia argyi H.Le ' v. & Vaniot. Their structures were characterized utilizing extensive spectroscopic methods. All isolates were evaluated for the LPS-induced nitric oxide (NO) production inhibitory activity and one compound exhibited activity with IC50 = 37.95 +/- 4.39 mu M.
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