A new rearranged limonoid and a new benzopyran from Harrisonia perforata

Two new compounds, a rearranged limonoid (harriforanoid) and a benzopyran (harriforanone) were isolated from the leaves and stems of Harrisonia perforata (Blanco) Merr., together with three known limonoids and fourteen known chromones. The structures of the compounds were elucidated using spectroscopic analysis. The experimental and calculated ECD spectra were used to characterize the absolute configuration of harriforanone. The cytotoxicity of each compound was assessed towards cholangiocarcinoma (KKU-100) and human liver cancer (HepG2) cell lines. However, none of these compounds exhibited any activity (IC50 > 50 mu M).

Automated summary

Two new compounds, a rearranged limonoid (harriforanoid) and a benzopyran (harriforanone), were isolated from the leaves and stems of Harrisonia perforata, along with three known limonoids and fourteen known chromones. The structures of the compounds were determined using spectroscopic analysis, and the absolute configuration of harriforanone was characterized using experimental and calculated ECD spectra. However, none of the compounds showed cytotoxic activity against cholangiocarcinoma and human liver cancer cell lines.