Isoflavanquinones from Abrus precatorius roots with their antiproliferative and anti-inflammatory effects

Phytochemical studies on the root of Abrus precatorius Linn. (Fabaceae), leads towards the identification of four undescribed (abruquinones M, N, O, and P), and seven known abruquinones, (abruquinones A, E, B, F, I, D, and G). Spectroscopic analyses (1D, and 2D NMR, HRESI-MS) were used in elucidating structures of the all compounds. Evaluation of anticancer activities of the isolated isoflavanquinones revealed that abruquinones M, and N showed cytotoxicity against oral CAL-27 (IC50 values 6.48 and 5.26 mu M, respectively), and colon (Caco-(2)) cell lines (IC50 values 15.79 and 10.33 mu M, respectively). Abruquinone M also inhibited the growth of lung cancer cells (NCI-H460) with IC50 of 31.33 mu M. The isolated isoflavanquiones also showed potent anti-inflammatory potential through phagocyte oxidative burst and pro-inflammatory cytokine TNF-alpha inhibition in vitro. These findings suggest isoflavanquinones from A. precatorius roots as candidates for further research in cancer treatment.

Automated summary

Phytochemical studies on the root of Abrus precatorius Linn. identified several new and known abruquinones, showing potential anticancer and anti-inflammatory activities, particularly demonstrating significant cytotoxicity and inhibition in oral, colon, and lung cancer cell lines. These findings suggest the isoflavanquinones from A. precatorius roots as promising candidates for further research in cancer treatment.