Journal
PHARMACOPSYCHIATRY
Volume 55, Issue 2, Pages 109-114Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/a-1589-6301
Keywords
treatment-resistant depression; ketamine; working memory
Categories
Funding
- Taipei Veterans General Hospital [V106B- 020, V107B- 010, V107C- 181, V108B- 012, V110C-025, V110B-002]
- Yen Tjing Ling Medical Foundation [CI110-30]
- Ministry of Science and Technology, Taiwan [101- 2314B-010-060, 102- 2314-B-010- 060, 107- 2314-B-075- 063-MY3, 108-2314- B-075 - 037, 110-2314-B-075-026, 110-2314-B-075024-MY3]
- Kun-Po Soo Medical Foundation
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Pretreatment working memory function may predict the treatment response to low-dose ketamine infusion in patients with treatment-resistant depression. Patients with poorer working memory function at baseline may show a better response to ketamine infusion.
Introduction Pretreatment neurocognitive function may predict the treatment response to low-dose ketamine infusion in patients with treatment-resistant depression (TRD). However, the association between working memory function at baseline and the antidepressant efficacy of ketamine infusion remains unclear. Methods A total of 71 patients with TRD were randomized to one of three treatment groups: 0.5mg/kg ketamine, 0.2mg/kg ketamine, or normal saline. Depressive symptoms were measured using the 17-item Hamilton Depression Rating Scale (HDRS) at baseline and after treatment. Cognitive function was evaluated using working memory and go-no-go tasks at baseline. Results A generalized linear model with adjustments for demographic characteristics, treatment groups, and total HDRS scores at baseline revealed only a significant effect of working memory function (correct responses and omissions) on the changes in depressive symptoms measured by HDRS at baseline (F=12.862, p<0.05). Correlation analysis further showed a negative relationship (r=0.519, p=0.027) between pretreatment working memory function and changes in HDRS scores in the 0.5mg/kg ketamine group. Discussion An inverse relationship between pretreatment working memory function and treatment response to ketamine infusion may confirm that low-dose ketamine infusion is beneficial and should be reserved for patients with TRD.
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