Journal
PHARMACOLOGY & THERAPEUTICS
Volume 229, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pharmthera.2021.107921
Keywords
Lycium barbarum polysaccharides; Immunoregulation; TLR; CR3; Gut microbiota
Categories
Funding
- Technology Major Projects for Major New Drugs Innovation and Development [2019ZX09J19101]
- National Natural Science Foundation of China [81001652]
Ask authors/readers for more resources
Lycium barbarum polysaccharides (LBPs), the most valuable and well-researched component of Lycium barbarum, possess antiaging, antidiabetic, antifibrotic, neuroprotective, and immunomodulation properties. Recent studies have provided insights into the structure-activity relationships, receptor recognition, and gut microbiota modulation of LBPs.
Lycium barbarum is widely used as a functional food and medicinal herb to promote health and longevity in China and in some other Asian countries. In modern pharmacological and chemical studies, the most valuable and well-researched component of L. barbarum is a group of unique water-soluble glycoconjugates that are collectively termed Lycium barbarum polysaccharides (LBPs). Numerous modern pharmacological studies have revealed that LBPs possess antiaging, antidiabetic, antifibrotic, neuroprotective, and immunomodulation properties, while the immunomodulatory effect is primary and is involved in other activities. However, due to their structural heterogeneity and lack of chromophores, it has long been unclear how LBPs work on the immune system. A few studies have recently provided some insights into the proposed mode of action of LBPs, such as structure-activity relationships, receptor recognition, and gut microbiota modulation of LBPs. This review provides a comprehensive overview of the immunoregulating properties of LBPs and their related mechanisms of action. (C) 2021 Elsevier Inc. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available