Journal
PHARMACOLOGICAL RESEARCH
Volume 169, Issue -, Pages -Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phrs.2021.105604
Keywords
Diabetes mellitus; Polyphenols; Nano-based drug delivery systems; Drug targeting
Categories
Funding
- FCT/MCTES [UIDB/50006/2020, UID/DTP/04138/2020]
- Fundacao para a Ciencia e Tecnologia (FCT)/Ministerio da Ciencia, Tecnologia e Ensino Superior (MCTES) [PTDC/MED-QUI/29241/2017 - POCI-01-0145-FEDER-029241]
- Programa Operacional Competitividade e Internacionalizacao (COMPETE)
- European Union (FEDER funds through the Operational Competitiveness Program (COMPETE)) [POCI-01-0145-FEDER-029253, POCI-01-0145-FEDER-029248]
- Fundacao para a Ciencia e a Tecnologia (FCT) [PD/BD/145169/2019]
- Fundação para a Ciência e a Tecnologia [PD/BD/145169/2019] Funding Source: FCT
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The review highlights the potential of nano-based drug delivery systems in enhancing the antidiabetic properties of polyphenols, offering a new avenue of research in the field of diabetology.
Diabetes mellitus is one of the biggest health emergencies of the 21st century worldwide, characterized by deficiency in insulin secretion and/or action, leading to hyperglycemia. Despite the currently available antidiabetic therapeutic options, 4.2 million people died in 2019 due to diabetes. Thus, new effective interventions are required. Polyphenols are plant secondary metabolites and have been recognized for their vast number of biological activities, including potential antidiabetic effects. However, the poor bioavailability and high metabolization of polyphenols restrict their biological effects in vivo. Nanotechnology is a promising area of research to improve the therapeutic effect of several compounds. Therefore, this review provides an overview of the literature about the utility of nano-based drug delivery systems as vehicles of polyphenols in diabetes treatment. It was possible to conclude that, in general, nano-based drug delivery systems can potentiate the beneficial antidiabetic properties of polyphenols, when compared with the free compounds, opening a new field of research in diabetology.
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