Journal
PHARMACOLOGICAL RESEARCH
Volume 173, Issue -, Pages -Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phrs.2021.105910
Keywords
Fibrosis; Epigenetic regulation; DNA methylation; Histone modification; Noncoding RNAs (ncRNAs); N6-methyladenosine modification (m6A)
Categories
Funding
- National Natural Science Foundation of China [81873580]
- Clinical Research Innovation Project, West China Hospital, Sichuan University [2019HXCX05]
- Shanghai Pharmaceuticals Holding Co., ltd.
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Fibrosis, a common process of chronic inflammatory diseases, leads to scar formation and functional failure in organs. Epigenetic mechanisms play a crucial role in fibrosis, involving DNA methylation, histone modification, ncRNAs, and m6A modification. Targeted therapy based on epigenetics holds great potential for treating fibrosis.
Fibrosis, a common process of chronic inflammatory diseases, is defined as a repair response disorder when organs undergo continuous damage, ultimately leading to scar formation and functional failure. Around the world, fibrotic diseases cause high mortality, unfortunately, with limited treatment means in clinical practice. With the development and application of deep sequencing technology, comprehensively exploring the epigenetic mechanism in fibrosis has been allowed. Extensive remodeling of epigenetics controlling various cells phenotype and molecular mechanisms involved in fibrogenesis was subsequently verified. In this review, we summarize the regulatory mechanisms of DNA methylation, histone modification, noncoding RNAs (ncRNAs) and N6-methyladenosine (m6A) modification in organ fibrosis, focusing on heart, liver, lung and kidney. Additionally, we emphasize the diversity of epigenetics in the cellular and molecular mechanisms related to fibrosis. Finally, the potential and prospect of targeted therapy for fibrosis based on epigenetic is discussed.
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