Decoding the complexity of circular RNAs in cardiovascular disease

Circular RNAs (circRNAs) are a new class of covalently circularized noncoding RNAs widely expressed in the human heart. Emerging evidence suggests they have a regulatory role in a variety of cardiovascular diseases (CVDs). This review's current focus includes our understanding of circRNA classification, biogenesis, function, stability, degradation mechanisms, and their roles in various cardiovascular disease conditions. Our knowledge of circRNA, the relatively recent member of the noncoding RNA family, is still in its infancy; however, recent literature proposes circRNAs may be promising targets for the understanding and treatment of CVD.

Automated summary

Circular RNAs (circRNAs) are a newly discovered class of noncoding RNAs found widely in the human heart, with emerging evidence suggesting they play regulatory roles in various cardiovascular diseases. Current understanding of circRNA focuses on their classification, biogenesis, function, stability, degradation mechanisms, and their potential as promising targets for understanding and treating CVD.