SYNTHESIS AND ANTIFUNGAL ACTIVITY EVALUATION OF 1-(2-BENZYLOXY-2-PHENYLETHYL)-1,2,3-TRIAZOLE MICONAZOLE ANALOGS

A series of 1-(2-aryloxy-2-phenylethyl)-1,2,3-triazole derivatives (Miconazole analogs) was obtained via copper catalyzed azide-alkyne cycloaddition as the key step. The synthesized compounds were evaluated for antimicrobial activity against Candida genus strains as well as filamentous fungi (Mucor hiemalis, Aspergillus fumigatus and Rhizopus oryzae). A 1-(2-aryloxy-2-phenylethyl)-1,2,3-triazole derivative exhibited remarkable selectivity comparable to that of Itraconazole against Rhizopus oryzae.

Automated summary

A series of 1-(2-aryloxy-2-phenylethyl)-1,2,3-triazole derivatives, synthesized via copper catalyzed azide-alkyne cycloaddition, showed potential antimicrobial activity against Candida genus strains and filamentous fungi. One derivative exhibited remarkable selectivity comparable to that of Itraconazole against Rhizopus oryzae.