4.0 Article

Rapid response to secukinumab in a 5-year-old with deficiency of the interleukin-36 receptor antagonist (DITRA) with severe scalp and nail involvement

Journal

PEDIATRIC DERMATOLOGY
Volume 38, Issue 5, Pages 1258-1263

Publisher

WILEY
DOI: 10.1111/pde.14737

Keywords

Deficiency of interleukin-36 receptor antagonist; generalized pustular psoriasis; secukinumab

Funding

  1. Shenzhen Innovation and Technology Commission Foundation [JCYJ20180306173356306]

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DITRA, caused by mutations of the IL36RN gene, is characterized by severe symptoms such as acute generalized pustular psoriasis, fever, and leukocytosis, but shows a rapid response to secukinumab in some cases.
Deficiency of the interleukin-36 receptor antagonist (DITRA) is an autosomal recessive disease caused by mutations of the IL36RN gene. DITRA is characterized by acute generalized pustular psoriasis (GPP), fever, systemic inflammation, and leukocytosis. We report the case of a 5-year-old girl with severe scalp and nail involvement with a rapid response to secukinumab.

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