Journal
PEDIATRIC DERMATOLOGY
Volume 38, Issue 5, Pages 1258-1263Publisher
WILEY
DOI: 10.1111/pde.14737
Keywords
Deficiency of interleukin-36 receptor antagonist; generalized pustular psoriasis; secukinumab
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Funding
- Shenzhen Innovation and Technology Commission Foundation [JCYJ20180306173356306]
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DITRA, caused by mutations of the IL36RN gene, is characterized by severe symptoms such as acute generalized pustular psoriasis, fever, and leukocytosis, but shows a rapid response to secukinumab in some cases.
Deficiency of the interleukin-36 receptor antagonist (DITRA) is an autosomal recessive disease caused by mutations of the IL36RN gene. DITRA is characterized by acute generalized pustular psoriasis (GPP), fever, systemic inflammation, and leukocytosis. We report the case of a 5-year-old girl with severe scalp and nail involvement with a rapid response to secukinumab.
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