Journal
PEDIATRIC BLOOD & CANCER
Volume 68, Issue 11, Pages -Publisher
WILEY
DOI: 10.1002/pbc.29285
Keywords
pediatric lymphoma; PTCL
Categories
Funding
- Kinderkrebsinitiative Buchholz, Holm-Seppensen (KKI)
- Deutsche Kinderkrebsstiftung
- Deutscher Akademischer Austauschdienst (DAAD) [57378443]
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Genetic analysis of PTCL in children, adolescents, and young adults revealed differences from adult cases, with most patients having detectable genetic variants but some showing no mutations. Variants commonly found in adults, such as TP53 and RHOA, were not identified in this group of CAYA PTCL patients.
Non-anaplasticperipheral T-cell lymphomas (PTCL) are rare tumors in children, adolescents, and young adults (CAYA) with poor prognosis and scarce genetic data. We analyzed lymphoma tissue from 36 patients up to 18 years old with PTCL, not otherwise specified (PTCL-NOS), hepatosplenic T-cell lymphoma, Epstein-Barr virus (EBV)-positive T-lymphoproliferative diseases, subcutaneous panniculitis-like T-cell lymphoma, and other PTCL types. Twenty-three patients (64%) had at least one genetic variant detectable, including TET2, KMT2C, PIK3D, and DMNT3A. TP53 and RHOA variants, commonly found in adults, were not identified. Eight of 20 (40%) CAYA PTCL-NOS had no detectable mutations. The genetic findings suggest that CAYA PTCL differ from adult cases.
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