Journal
PEDIATRIC AND DEVELOPMENTAL PATHOLOGY
Volume 24, Issue 6, Pages 570-574Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/10935266211021222
Keywords
peritoneum; pericardium; mesothelioma; RNA sequencing; immunohistochemistry; EWSR1; gene rearrangement
Categories
Ask authors/readers for more resources
This article presents two pediatric cases of EWSR1-ATF1 translocation-associated malignant mesothelioma in the peritoneum and pericardium, both lacking a known exposure history. Microscopic examination revealed predominantly epithelioid morphology with positive immunohistochemistry results, and RNA sequencing confirmed EWSR1-ATF1 gene rearrangement in both cases.
Malignant mesothelioma is a neoplasm of serosal surfaces, most commonly affecting the pleura. The peritoneum, pericardium, and tunica vaginalis are less frequently involved. Malignant mesothelioma with EWSR1-ATF1 fusion in young adults was recently reported in the literature. Here, we present two pediatric cases of EWSR1-ATF1 translocation-associated malignant mesothelioma in the peritoneum and pericardium respectively. Both cases lacked a known exposure history. Microscopy in both cases showed predominantly epithelioid morphology with ample eosinophilic cytoplasm, and immunohistochemistry was positive for pan-keratin, calretinin, and WT1. Both cases showed EWSR1-ATF1 gene rearrangement by RNA sequencing, which was instrumental in confirming the diagnosis of malignant mesothelioma and to exclude more common pediatric sarcomas, especially in the context of limited sampling.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available