Journal
PEDIATRIC AND DEVELOPMENTAL PATHOLOGY
Volume 24, Issue 6, Pages 581-584Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/10935266211025122
Keywords
PediPath; placenta; fetal; infections; infectious; immunohistochemistry; neonatal; pediatric
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Placental infection by SARS-CoV-2 can lead to various pathologic alterations. Despite extensive placental pathology, fetal transmission of SARS-CoV-2 did not occur in this case, suggesting a potential relationship between placental infection, inflammation, and fibrin deposition.
Placental infection by SARS-CoV-2 with various pathologic alterations reported. Inflammatory findings, such as extensive perivillous fibrin deposition and intervillous histiocytosis, have been postulated as risk factors for fetal infection by SARS-CoV-2. We describe the placental findings in a case of a 31-year-old mother with SARS-CoV-2 infection who delivered a preterm female neonate who tested negative for SAR-CoV2 infection. Placental examination demonstrated a small for gestational age placenta with extensive intervillous histiocytosis, syncytiotrophoblast karyorrhexis, and diffuse intervillous fibrin deposition. Immunohistochemical staining demonstrated infection of the syncytiotrophoblasts by SARS-CoV-2 inversely related to the presence of intervillous histiocytes and fibrin deposition. Our case demonstrates that despite extensive placental pathology, no fetal transmission of SARS-CoV-2 occurred, as well as postulates a relationship between placental infection, inflammation, and fibrin deposition.
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