Journal
PATHOLOGY RESEARCH AND PRACTICE
Volume 224, Issue -, Pages -Publisher
ELSEVIER GMBH
DOI: 10.1016/j.prp.2021.153536
Keywords
CircPVT1; MiR-30e; DLL4; CeRNA; T cell acute lymphoblastic leukemia
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The study revealed that circPVT1 is involved in the progression of T-ALL and is associated with patient prognosis, indicating it may represent a potential therapeutic target for T-ALL treatment.
T cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic cancer with dismal prognosis. Recent studies disclosed that circPVT1 played an oncogene role in various cancers. But its role in T-ALL is still unclear. In this study, we found the expression levels of circPVT1 in bone marrows and cell lines of T-ALL were significantly up regulated and knock-down of circPVT1 in T-ALL cell lines could inhibit the cell proliferation and increase the cell apoptosis. Further analysis showed that circPVT1 could bind directly to miR-30e and contributed to the activate the Notch signaling by regulating miR-30e/DLL4 pathway. The levels of circPVT1 were obviously related to cumulative relapse rate and 5-year survival rate. In conclusion, our study reveals that circPVT1 participates in the progression of T-ALL through the miR-30e/DLL4 pathway and might represent a potential therapeutic target for T-ALL treatment.
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