Journal
FUTURE ONCOLOGY
Volume 12, Issue 13, Pages 1553-1563Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/fon-2016-0130
Keywords
chemotherapy; hematologic/lymphoma; molecular oncology
Categories
Funding
- Celgene Corporation, Summit, NJ, USA
- Celgene
- Mundipharma
- Teva
- Menarini
- AbbVie
- Seattle Genetics
- Roche
- Celgene Corporation
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Activated B-cell-like (ABC) diffuse large B-cell lymphoma (DLBCL), the major constituent of nongerminal center B-cell-like (non-GCB) DLBCL, is associated with poorer survival outcomes than GCB-type DLBCL. In Phase II studies, lenalidomide combined with R-CHOP (R-2-CHOP) improved outcomes relative to historical R-CHOP in newly diagnosed DLBCL, particularly in non-GCB cases. ROBUST (CC-5013-DLC-002) is a randomized, double-blind, global, PhaseIII study of oral lenalidomide (15 mg, days 1-14) plus R-CHOP21 x 6 versus placebo-RCHOP21x6 in patients with previously untreated ABC-type DLBCL. Subtyping is done within 3 calendar days by central laboratory gene-expression profiling of formalin-fixed paraffin-embedded biopsy tissue. The primary end point is progression-free survival. Secondary end points include response rates, overall survival and health-related quality of life.
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