Journal
FUTURE ONCOLOGY
Volume 12, Issue 3, Pages 323-331Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/fon.15.325
Keywords
CRC; IHC; MMPs; prognosis
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Funding
- King Abdulaziz City for Science and Technology (KACST) [ARP-30-262]
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Aim: To evaluate the expression pattern of matrix metalloproteinases (MMPs); MMP-2, MMP-7 and MMP-9 in colorectal cancer (CRC) and determine its prognostic potential. Patients & methods: CRC samples of 127 patients were studied. Protein expressions of MMP-2, -7 and -9 were analyzed by immunohistochemistry and association with clinicopathological variables was statistically analyzed. Results: Overexpressions of MMP-2 and MMP-9 correlated with poor outcome as evaluated by univariate Kaplan-Meier for disease-free survival (p = 0.04, p = 0.0001) and disease-specific survival (p = 0.01, p = 0.01), respectively. Cox analysis of MMP-2 and -9 were significant independent predictors of disease-free survival (p = 0.006, p = 0.018) and disease-specific survival (p = 0.004, p = 0.049), respectively. Conclusion: MMPs expression patterns provide useful prognostic information in CRC, while predicting the patients at high risk for recurrent disease.
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