Pd-Catalyzed Etherification of Nitroarenes

The Pd-catalyzed etherification of nitroarenes with arenols has been achieved using a new rationally designed ligand. Mechanistic insights were used to design the ligand so that both the oxidative addition and reductive elimination steps of a plausible catalytic cycle were facilitated. The catalytic system established here provides direct access to a range of unsymmetrical diary! ethers from nitroarenes.

Automated summary

Through the use of a new designed ligand, Pd-catalyzed etherification of nitroarenes with arenols was achieved, allowing for the direct access to a range of unsymmetrical diaryl ethers. The design of the ligand facilitated both the oxidative addition and reductive elimination steps of the catalytic cycle, providing mechanistic insights for optimizing the reaction.