Journal
ORGANIC PROCESS RESEARCH & DEVELOPMENT
Volume 25, Issue 6, Pages 1360-1365Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.oprd.0c00553
Keywords
synthesis; [6]-paradol; vanillin; Wittig-Horner reaction; Grignard reaction
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Funding
- Anhui Province Natural Science Foundation [1808085QC77]
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In this study, an efficient synthesis of [6]-paradol was achieved in four steps with a 72.0% overall yield. The method utilized commercially available materials and allowed for convenient isolation with multiple crystallization without the need for column chromatography, resulting in a high-purity product of over 99.2% purity that is suitable for large-scale synthesis.
Y An efficient synthesis of [6]-paradol (1) has been performed in four steps with a 72.0% overall yield. The present method highlights commercially available materials, convenient isolation with multiple crystallization without involving column chromatography, and a high-purity product (more than 99.2%), and it is amenable to large-scale synthesis.
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