Sulfur-Directed C7-Selective Alkenylation of Indoles under Rhodium Catalysis

Regioselective direct functionalization of an indole benzenoid fragment has been a significant challenge because of its inherently lower reactivity. In this report, we introduce a Rh-catalyzed C-7-selective alkenylation of indole derivatives using a new sulfur directing group N-SCy. A notable feature of this system is that the directing group is readily installed to the indoles and easily removed after the catalysis under mild conditions.

Automated summary

This report introduces a Rh-catalyzed C-7-selective alkenylation of indole derivatives using a new sulfur directing group N-SCy, which is easily installed to the indoles and removed after the catalysis under mild conditions.