Journal
ORGANIC LETTERS
Volume 23, Issue 11, Pages 4473-4477Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.1c01412
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Funding
- National Natural Science Foundation of China [21672047]
- Science and Technology Plan of Shenzhen [JCYJ20180306172044124]
- Natural Science Foundation of Guangdong [2020A1515010564]
- Shenzhen Government
- Guangdong Province Covid-19 Pandemic Control Research Fund [2020KZDZX1218]
- Open Research Fund of the School of Chemistry and Chemical Engineering, Henan Normal University
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A multicomponent carbonyl alkylative amination reaction using tetrabutylammonium decatungstate as a photocatalyst was described. Various N-arylamines, aldehydes, and hydrocarbons were examined as reaction substrates, yielding the corresponding alpha-branched tertiary and secondary amines in good to moderate yields. The reaction proceeds through the generation of alkyl radicals via a light-promoted hydrogen atom transfer process followed by free radical addition to iminium ions generated in situ.
A multicomponent carbonyl alkylative amination reaction is described. A variety of N-arylamines, aldehydes, and hydrocarbons have been examined as reaction substrates using tetrabutylammonium decatungstate as photocatalyst, providing the corresponding alpha-branched tertiary and secondary amines in good to moderate yields. The reaction proceeds through the generation of alkyl radicals by a light-promoted hydrogen atom transfer process followed by free radical addition to iminium ions generated in situ.
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