Difunctionalization of Alkynones by Base-Mediated Reaction with α,α-Dithioketones

A novel 1,2-difunctionalization of alkynones via an umpolung strategy for the synthesis of tetrasubstituted olefins has been developed. This procedure is realized by a formal C-C sigma-bond cleavage reaction of cyclic alpha,alpha-dithioketones and subsequent deprotection. Notable features of this approach include excellent yields, mild reaction conditions, a broad substrate scope, and operational simplicity.

Automated summary

A novel 1,2-difunctionalization of alkynones has been developed via an umpolung strategy for the synthesis of tetrasubstituted olefins. The approach features excellent yields, mild reaction conditions, a broad substrate scope, and operational simplicity.