Journal
ORGANIC LETTERS
Volume 23, Issue 11, Pages 4284-4288Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.1c01231
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Funding
- JSPS KAKENHI [JP 15KT0063]
- Platform Project for Supporting Drug Discovery and Life Science Research (Basis for Supporting Innovative Drug Discovery and Life Science Research (BINDS)) from AMED [JP21am0101084]
- Cooperative Research Program of the Network Joint Research Center for Materials and Devices of the Ministry of Education, Culture, Sports, Science and Technology (MEXT)
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The developed one-iridium-catalyst system efficiently transforms 1,7-enynes into substituted indole derivatives, providing a straightforward synthetic approach to valuable indoles with vinyl and silylmethyl groups at specific positions.
We have developed a one-iridium-catalyst system that transforms Nallyl-N-sulfonyl-2-(silylalkynyl)aniline derivatives, which are 1,7-enynes in which both multiple bonds have a heteroatom, to the corresponding substituted indole derivatives via isomerization/cycloisomerization/aromatization. This strategy provides an atom-economical and straightforward synthetic approach to a series of valuable indoles having vinyl and silylmethyl groups at the 2- and 3-positions.
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