Journal
ORGANIC LETTERS
Volume 23, Issue 12, Pages 4667-4671Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.1c01410
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Funding
- BK21 Plus Program
- National Research Foundation (NRF) - Ministry of Science, Information and Communications Technology (ICT) & Future Planning, Korea [2021R1A4A2001251, 2019R1A2C2085749]
- National Research Foundation of Korea [2019R1A2C2085749] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Psammocindoles A-C, a new class of indole alkaloids isolated from a Psammocinia vermis sponge, were found to significantly stimulate adiponectin secretion in human bone marrow mesenchymal stem cells.
Psammocindoles A-C (1-3), a new class of indole alkaloids, were isolated from a Psammocinia vermis sponge. By combined spectroscopic analyses, the structures of these compounds were determined to be the indole-.-lactams derived from three amino acid residues. In addition, an enantiomer psammocindole D (4), and the N-lactam isomers isopsammocindoles A-D (5-8) were also synthesized. These natural products and synthetic analogues were found to significantly stimulate adiponectin secretion in human bone marrow mesenchymal stem cells.
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