Rhodium-Catalyzed Reductive trans-Alkylacylation of Internal Alkynes via a Formal Carborhodation/C-H Carbonylation Cascade

A rhodium-catalyzed reductive annulation cascade reaction that consists of a formal anti-carborhodation of a C C bond and an aromatic C-H carbonylation cascade for producing cyclopenta[de]quinoline-2,5(1H,3H)-diones is described. This method uses the Mn reductant to reductively regenerate the active rhodium species, hence obviating the need for prefunctionalization, and represents a new route to the carbonylation of aromatic C-H bonds with alkynes leading to aryl vinyl ketone frameworks.

Automated summary

This method of rhodium-catalyzed reductive annulation cascade reaction avoids the need for prefunctionalization by using the Mn reductant to reductively regenerate the active rhodium species. It provides a new route for the carbonylation of aromatic C-H bonds with alkynes leading to aryl vinyl ketone frameworks.