Journal
ORGANIC LETTERS
Volume 23, Issue 18, Pages 7144-7149Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.1c02558
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Funding
- National Natural Science Foundation of China [21901197]
- Natural Science Basic Research Plan in Shaanxi Province of China [2019JM093]
- Guangdong Provincial Key Laboratory of Catalysis [2020B121201002]
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The synergistic utilization of copper catalysis and proton-transfer catalysis allows for an atom- and step-economic aza-[4 + 2] cycloaddition reaction between N-arylamino carbonyl compounds and simple 1,3-dienes. This operationally simple protocol provides a green, rapid, and efficient access to 1,2,3,6-tetrahydropyridines with a broad scope.
We describe a synergistic utilization of copper catalysis and proton-transfer catalysis that enables an atom- and step-economical aza-[4 + 2] cycloaddition reaction of readily available N-arylamino carbonyl compounds with simple 1,3-dienes. The reaction proceeds smoothly under an air atmosphere and produces water as the sole side product. Whereas the amines can directly serve as the C- and N-atom donors, this operationally simple protocol provides green, rapid, and efficient access to 1,2,3,6-tetrahydropyridines with a broad scope.
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