Journal
ORGANIC LETTERS
Volume 23, Issue 13, Pages 4976-4980Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.1c01382
Keywords
-
Categories
Funding
- National Science Fund for Distinguished Young Scholars [81625021]
- National Natural Science Foundation of China [81872764]
- Guangdong Joint Fund of the National Natural Science Foundation of China [U1801288]
Ask authors/readers for more resources
For the first time, the 15-membered cyclic depsipeptide boholamide A and an epimer were prepared by total synthesis, leading to a revision of the C6 stereochemistry in the original proposed structure. The revised boholamide A was synthesized in 16 linear steps with an overall yield of 5.46%, facilitating investigations into its potential as a hypoxia-selective anticancer agent.
The 15-membered cyclic depsipeptide boholamide A and an epimer were prepared by total synthesis for the first time, thus leading to a revision of C6 stereochemistry in the originally proposed structure of natural boholamide A. This convergent route features achievement of a macro-lactamization step in a gram scale. The revised boholamide A was sythesized with 16 linear steps in 5.46% overall yield. This work facilitates the investigations of boholamide A as a potential hypoxia-selective anticancer agent.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available