Journal
ORGANIC LETTERS
Volume 23, Issue 15, Pages 5766-5771Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.1c01929
Keywords
-
Categories
Funding
- Natural Science Foundation of Zhejiang Province [LQ19B020003, LY21B020003]
- National Natural Science Foundation of China [21602022]
- Chengdu Talents Program
- 1000 Talents Program of Sichuan Province
- Longquanyi District Talents Program
- Science and Technology Program of Sichuan Province [2018JY0345]
- Jinhua Branch of Sichuan Industrial Institute of Antibiotics [1003]
- Chengdu University [2081915037]
Ask authors/readers for more resources
In this study, alkynylated imidazo[1,5-a]indoles and alpha,alpha-difluoromethylene tetrasubstituted alkenes were successfully synthesized via Rh(III)-catalyzed [4 + 1] annulation/alkyne moiety migration and C-H alkenylation/DG migration, showing excellent product selectivity, high yields, and good tolerance of functional groups.
Herein, we report the divergent synthesis of alkynylated imidazo[1,5-a]indoles and alpha,alpha-difluoromethylene tetrasubstituted alkenes through Rh(III)-catalyzed [4 + 1] annulation/alkyne moiety migration and C-H alkenylation/DG migration, respectively. This protocol features tunable product selectivity, excellent chemo-, regio-, and stereoselectivity, broad substrate scope, moderate to high yields, good tolerance of functional groups, and mild redox-neutral conditions.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
