Journal
ORGANIC LETTERS
Volume 23, Issue 15, Pages 6004-6009Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.1c02074
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Funding
- National Natural Science Foundation of China [21772217]
- National Key RAMP
- D Program of China [2016YFA0202900]
- Strategic Priority Research Program of the Chinese Academy of Sciences [XDB20000000]
- Science and Technology Commission of Shanghai Municipality [18XD1405000]
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An efficient nickel-catalyzed addition of benzyl nitriles to terminal vinyl ketones via C(sp(3))-H functionalization has been developed, providing a novel protocol for the synthesis of α-functionalized benzyl nitriles with structural diversity under mild reaction conditions without the use of a strong base. This work might be potentially useful towards the development of an enantioselective variant using chiral nitrogen ligands.
An efficient nickel(0)-catalyzed addition of benzyl nitriles to terminal vinyl ketones via C(sp(3))-H functionalization has been developed. The reaction provides a novel and efficient protocol for the synthesis of a-functionalized benzyl nitriles with a wide range of structural diversity under mild reaction conditions while obviating the use of a strong base. The work might be potentially useful toward the development of an enantioselective variant using chiral nitrogen ligands.
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