Journal
ORGANIC LETTERS
Volume 23, Issue 15, Pages 5952-5957Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.1c02049
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Funding
- Science and Technology Support Program of Jiangsu Province [BE2017643]
- State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College [GTZK201905]
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A novel reaction method has been developed for the synthesis of 4-arylisoquinolones using 3-arylisoxazolones and propargyl alcohols. This research expands the potential applications of isoxazolones in organic synthesis and important biological compound synthesis.
The Rh(III)-catalyzed dual directing group assisted C-H activation/annulation of 3-arylisoxazolones with propargyl alcohols has been developed, which expands the application scope of isoxazolones in organic synthesis. This protocol also worked well with 3-aryl-1,4,2-dioxazol-5-ones to produce synthetically and biologically important 4-arylisoquinolones.
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