Journal
ORGANIC LETTERS
Volume 23, Issue 15, Pages 5947-5951Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.1c02041
Keywords
-
Categories
Funding
- Saarland University
Ask authors/readers for more resources
Protected dipeptides can be converted into cyclic ketoaminals, which can undergo palladium-catalyzed regioselective C-H functionalization. The use of the MTA directing group was found to be superior to the commonly used AQ group. Incorporation of modified dipeptides into larger peptide chains is possible after cleavage of the directing and protecting groups.
Protected dipeptides can be converted into cyclic ketoaminals, which can be subjected to palladium-catalyzed regioselective C-H functionalization. The best results are obtained using the 2-(methylthio)aniline (MTA) directing group, which is superior to the commonly used 8-aminoquinoline (AQ) group. No epimerization of stereogenic centers is observed. Subsequent cleavage of the directing and protecting groups allows the incorporation of a modified dipeptide into larger peptide chains.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available