Journal
ORGANIC LETTERS
Volume 23, Issue 19, Pages 7688-7692Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.1c03024
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Funding
- Distinguished Scientist Fellowship Program (DSFP) at King Saud University, Riyadh, Saudi Arabia
- European Research Council ERC [692640]
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An efficient transition-metal-free cyclizing radical aminoboration of unactivated alkenes was achieved using B-2(OH)(4) reagent as the boron source. The cascade reaction initiated by the interaction between B-2(OH)(4) and an aryloxyamide N-radical precursor led to the formation of a wide range of high-value cyclic 1,2-aminoboronic esters. This transformation proceeds via cyclization of an N-radical with subsequent intermolecular C-radical borylation.
An efficient transition-metal-free cyclizing radical aminoboration of unactivated alkenes is reported. The B-2(OH)(4) reagent was used as the boron source, and the interaction between B-2(OH)(4) and an aryloxyamide N-radical precursor enabled the chain reaction to be initiated upon irradiation in the absence of any catalyst. This transformation proceeds via cyclization of an N-radical with subsequent intermolecular C-radical borylation. The cascade shows a broad scope and provides a wide range of high-value cyclic 1,2-aminoboronic esters.
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