Journal
ORGANIC LETTERS
Volume 23, Issue 17, Pages 6789-6794Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.1c02373
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Funding
- National Natural Science Foundation of China [21772046, 2193103]
- Guangdong Provincial Key Laboratory of Catalysis [2020B121201002]
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This protocol discloses a method to construct polysubstituted quinolin-3-amines using Mn(III) acetate as a mild one-electron oxidant promoting a radical process. It offers a practical approach with high reaction efficiency and good compatibility of functional groups, providing a straightforward access to functional quinoline derivatives.
Polysubstituted quinolin-3-amines are vital structural motifs because of their broad biological activities as well as versatile transformational abilities. However, they are not easily accessible. We disclose a protocol with Mn(III) acetate as a mild one-electron oxidant promoting a radical process to construct polysubstituted quinolin-3-amines. 2-(2-Isocyanophenyl)-acetonitriles and organoboron reagents are suitable substrates for this reaction. The remarkable advantages of this protocol are the practical method, mild approach, high reaction efficiency, and good compatibility of functional groups, providing straightforward access to functional quinoline derivatives.
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