Journal
FUTURE ONCOLOGY
Volume 12, Issue 5, Pages 617-624Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/fon.15.334
Keywords
conformal radiotherapy; individual radiosensitivity; predictive assays; prostate neoplasm; quality of life; toxicity
Categories
Funding
- German Academic Exchange Service
- Helmholtz foundation
- Dr Erich Schmitt foundation
Ask authors/readers for more resources
Aim: To identify predictive assays for radiation-induced toxicity in prostate cancer patients. Patients & methods: Patients have been surveyed prospectively before and up to 16 months after radiotherapy using a validated questionnaire. Subgroups of 25 patients with minor and larger score changes, respectively, were selected for gamma-H2AX, G(2) and Annexin V assays. Results: A significantly higher spontaneous chromatid aberration yield (HR: 1.46 [95% CI: 1.02-2.09]; p = 0.04), higher levels of early apoptotic (HR: 1.12 [95% CI: 1.01-1.24]; p = 0.04) and late apoptotic and necrotic (HR: 1.10 [95% CI: 0.99-1.23]; p = 0.08) lymphocytes 24 h postirradiation were found in patients with a bowel bother score decrease greater than 20 points more than 1 year after treatment. Conclusion: Chromatid aberration and apoptosis/necrosis assays appear to be suitable for the prediction of radiation-induced toxicity.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available