Journal
FUTURE MICROBIOLOGY
Volume 11, Issue 8, Pages 1035-1046Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/fmb-2015-0016
Keywords
biofilm; Candida species; propolis extract; virulence factors
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Funding
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (Cnpq)
- Fundacao Araucaria
- CAPES [946914-1]
- FCT for the Strategic Project unit [UID/BIO/04469/2013]
- FCT
- European Union funds (FEDERCOMPETE) [RECI/BBB-EBI/0179/2012 (FCOMP-01-0124-FEDER-027462)]
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Aim: To evaluate the effect of propolis against Candida species planktonic cells and its counterpart's biofilms. Materials & methods: The MIC values, time-kill curves and filamentation form inhibition were determined in Candida planktonic cells. The effect of propolis on Candida biofilms was assessed through quantification of CFUs. Results: MIC values, ranging from 220 to 880 mu g/ml, demonstrated higher efficiency on C. albicans and C. parapsilosis than on C. tropicalis cells. In addition, propolis was able to prevent Candida species biofilm's formation and eradicate their mature biofilms, coupled with a significant reduction on C. tropicalis and C. albicans filamentation. Conclusion: Propolis is an inhibitor of Candida virulence factors and represents an innovative alternative to fight candidiasis.
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