4.3 Article

The gut resistome is highly dynamic during the first months of life

Journal

FUTURE MICROBIOLOGY
Volume 11, Issue 4, Pages 501-510

Publisher

FUTURE MEDICINE LTD
DOI: 10.2217/fmb.15.154

Keywords

antibiotic resistance gene; bacteroides; birth mode; breastfeeding; gut microbiota; infant; metagenome; microbiome; pediatric; resistomes

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Aim: We investigated the longitudinal development of several antibiotic resistance genes (ARGs) of the infant gut resistome during the first months after birth. Materials & methods: Fecal samples from 120 infants collected at the ages of 5, 13 and 31 weeks were analyzed and subjected to qPCR for the detection of several ARGs. Results: The prevalence of ARGs significantly increased for ermB, tetM and tetQ, while it decreased for aac(6')-aph(2'). Birth mode and breastfeeding significantly affected tetQ prevalence. Correlations to bacterial taxa suggest that fluctuations in some ARGs are (partly) attributed to shifts in bacteroides colonization rates. Conclusion: Acquisition of ARGs in the gut microbiota occurs shortly after birth and resistome composition fluctuates over the course of several months, reflecting changes in microbial community structure.

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