Journal
FUTURE MEDICINAL CHEMISTRY
Volume 8, Issue 2, Pages 195-210Publisher
FUTURE SCI LTD
DOI: 10.4155/fmc.15.173
Keywords
antimicrobial resistance; bacterial pathogenicity; computational approaches; efflux pump inhibitor; molecular dynamics; multidrug efflux pump simulation; tripartite assembly
Categories
Ask authors/readers for more resources
Micro-organisms express a wide range of transmembrane pumps known as multidrug efflux pumps that improve the micro-organism's ability to survive in severe environments and contribute to resistance against antibiotic and antimicrobial agents. There is significant interest in developing efflux inhibitors as an adjunct to treatment with current and next generation of antibiotics. A greater understanding of drug recognition and transport by multidrug efflux pumps is needed to develop clinically useful inhibitors, given the breadth of molecules that can be effluxed by these systems. We summarize some structural and functional data that could provide insights into the inhibition of transport mechanisms of these intricate molecular nanomachines with a focus on the advances in computational approaches.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available