Journal
FUTURE MEDICINAL CHEMISTRY
Volume 8, Issue 9, Pages 993-1012Publisher
FUTURE SCI LTD
DOI: 10.4155/fmc-2016-0015
Keywords
detection; Enterobacteriaceae; inhibitors; mechanism; NDM-1; New Delhi metallo-beta-lactamase-1; substrates
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Since its discovery in 2008, New Delhi metallo-beta-lactamase-1 (NDM-1)-producing Enterobacteriaceae have disseminated globally, facilitated predominantly by gut colonization and the spread of plasmids carrying the bla(NDM-1) gene. With few effective antibiotics against NDM-1 producers, and resistance developing to those which remain, there is an urgent need to develop new treatments. To date, most drug design in this area has been focused on developing an NDM-1 inhibitor and has been aided by the wealth of structural and mechanistic information available from high resolution x-ray crystallography and molecular modeling. This review aims to summarize current knowledge regarding the detection of NDM-1 producers, the mechanism of action of NDM-1 and to highlight recent attempts toward the development of clinically useful inhibitors.
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