Journal
FUTURE MEDICINAL CHEMISTRY
Volume 8, Issue 11, Pages 1291-1316Publisher
Newlands Press Ltd
DOI: 10.4155/fmc-2016-0047
Keywords
anticancer; carboline; colchicine; design; drug; indole; structure-activity relationship; synthesis; tubulin inhibitors
Categories
Funding
- RFUMS-DePaul Pilot Grant
Ask authors/readers for more resources
Discovery of new indole-based tubulin polymerization inhibitors will continue to dominate the synthetic efforts of many medicinal chemists working in the field. The indole ring system is an essential part of several tubulin inhibitors identified in the recent years. The present review article will update the synthesis, anticancer and tubulin inhibition activities of several important new indole classes such as 2-phenylindoles (28, 29 & 30), oxindoles (35 & 38), indole-3-acrylamides (44), indolines (46), aroylindoles (49), carbozoles (75, 76 & 82), azacarbolines (87) and annulated indoles (100-105).
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available