Journal
FUTURE MEDICINAL CHEMISTRY
Volume 8, Issue 4, Pages 405-419Publisher
FUTURE SCI LTD
DOI: 10.4155/fmc.16.4
Keywords
endotype; IL-4; JAK-STAT pathway; phenotype; STAT6; therapy; 'Th2-high' severe asthma
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Severe asthma is a heterogeneous disease characterized by reversible airway obstruction, chronic inflammation and airway remodeling. Phenotyping and/or endotyping can lead to a more personalized treatment strategy, improving the efficacy of novel drugs. Atopic asthma is associated with high levels of Th2 cells, implicated in a number of inflammatory responses. Differentiation of these cells from naive T cells occurs primarily via the JAK-STAT signaling pathway. Targeting this pathway through inhibition of activating cytokines (IL-4 and IL-13) and their receptors, the JAKs or the STATs, has been shown to have a therapeutic effect on asthma pathology. There are a number of novel drugs currently in development, which target various pathway components; these include both biologics and small molecules at various stages of development.
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